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Levitra, available as film-coated tablet, is a widely used to treat patients who are suffering from problems regarding erection. Due to such problem for they cannot have fulfillment and pleasure while having sex. Levitra is available in 5, 10 and 20 mg tablet; each respectively includes 5.926, 11.852 and 23.705 mg of Vardenafil monohydrochloride trihydrate.
Erection of penis depends on the movement of smooth muscle in corpus cavernosum and its adjacent arterioles. When a man is stimulated sexually, nitric oxide is discharged from the nurve in corpus cavernosum. This nitric oxide make the enzyme guanylate cyclase active, which eventually increase the level of cyclic guanosine monophosphate in the corpus cavernosum. This process makes the muscles relaxed which enables increase in blood flow into the genital organ.
Vardenafil slows down PDE5, an enzyme that acts behind cGMP degradation in the corpus cavernosum, and thus increases the impact of endogenous nitric oxide that is produced in corpus cavernosum upon sexual stimulation. In this way, Levitra initiates natural response process of sexual stimulation.
Commonly the following dosage levels are prescribed for the patients.
- Initially the patient is prescribed to take a dose of 10 mg 25 to 60 minutes before having sex. Experiments have shown that if the drug is taken as far as 4 to 5 hours before having sex, it can still be effective. Patient should not take the medication more than once a day. Having any food is not necessary for this tablet. However, the patient has to be sexually aroused for desirable response.
- The highest and lowest quantity of dosage depends on the patient’s tolerance toward the drug and the efficacy of the tablet. Ideally the highest quantity should not exceed 20 mg and the lowest quantity should be 5 mg per day.
- If Levitra is taken as a combined drug, then the dosage differs. When taken combined with potent cytochrome P-450 inhibitors, ketoconazole, itraconazole, indinavir and ritonavir, maximum 5 mg of Levitra should be taken. When taken in combination with erythromycin, 10 mg should be the maximum dose a day.